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This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Mutations in this gene cause X-linked mental retardation and epilepsy. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007411 [axon guidance] GO:0010628 [positive regulation of gene expression] GO:0021759 [globus pallidus development] GO:0021772 [olfactory bulb development] GO:0021800 [cerebral cortex tangential migration] GO:0021831 [embryonic olfactory bulb interneuron precursor migration] GO:0021846 [cell proliferation in forebrain] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0030900 [forebrain development] GO:0042127 [regulation of cell proliferation] GO:0043565 [sequence-specific DNA binding] GO:0044241 [lipid digestion] GO:0046622 [positive regulation of organ growth] GO:0072148 [epithelial cell fate commitment]
