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DVL2

GENERAL INFORMATION

Gene name

 DVL2

Gene description

 Dishevelled segment polarity protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA022914 , CAB009312
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022914
CAB009312

GENE INFORMATION

Gene name

 DVL2

Synonyms

Description

 Dishevelled segment polarity protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7225341 - 7234545

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004975 (version 83.38)

Entrez gene

 1856

UniProt

 O14641 (UniProt - Evidence at protein level)

neXtProt

 NX_O14641

Antibodypedia

 DVL2 antibodies

PROTEIN BROWSER
DVL2-001
DVL2-004
DVL2-008
DVL2-010
DVL2-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DVL2-001
ENSP00000005340
ENST00000005340
O14641 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001843 [neural tube closure]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007379 [segment specification]
GO:0007507 [heart development]
GO:0016055 [Wnt signaling pathway]
GO:0019904 [protein domain specific binding]
GO:0022007 [convergent extension involved in neural plate elongation]
GO:0030136 [clathrin-coated vesicle]
GO:0031410 [cytoplasmic vesicle]
GO:0034613 [cellular protein localization]
GO:0035282 [segmentation]
GO:0035329 [hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042802 [identical protein binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043621 [protein self-association]
GO:0044340 [canonical Wnt signaling pathway involved in regulation of cell proliferation]
GO:0045177 [apical part of cell]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060029 [convergent extension involved in organogenesis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090103 [cochlea morphogenesis]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 736 aa
78.9 kDa 		No 0
DVL2-004
ENSP00000459797
ENST00000575458
I3L2N2 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0035556 [intracellular signal transduction]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
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 730 aa
78.4 kDa 		No 0
DVL2-008
ENSP00000459991
ENST00000575756
I3L2W9 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
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 363 aa
39.9 kDa 		No 0
DVL2-010
ENSP00000458209
ENST00000574143
I3L0M7 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
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 291 aa
32.1 kDa 		No 0
DVL2-016
ENSP00000458465
ENST00000575086
I3L0Z8 [Direct mapping]
Segment polarity protein dishevelled homolog DVL-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0035556 [intracellular signal transduction]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
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 300 aa
31.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.