Expression of PRSS22 in cancer - Summary - The Human Protein Atlas

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PRSS22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRSS22
Gene description	Protease, serine, 22
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, MCF7, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in exocrine glandular cells of pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA049161
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049161

GENE INFORMATION
Gene name	PRSS22 (HGNC Symbol)
Synonyms	BSSP-4, hBSSP-4, SP001LA
Description	Protease, serine, 22 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2852727 - 2858170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005001 (version 83.38)
Entrez gene	64063
UniProt	Q9GZN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZN4
Antibodypedia	PRSS22 antibodies

PROTEIN BROWSER

PRSS22-001	PRSS22-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS22-001 ENSP00000161006 ENST00000161006	Q9GZN4 [Direct mapping] Brain-specific serine protease 4 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	317 aa 33.7 kDa	Yes	0
PRSS22-002 ENSP00000458506 ENST00000571228	I3L116 [Direct mapping] Brain-specific serine protease 4 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	207 aa 21.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.