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UPF1

GENERAL INFORMATION

Gene name

 UPF1

Gene description

 UPF1 regulator of nonsense transcripts homolog (yeast)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA019587 , HPA020857
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and melanoma (unfavourable).
Renal cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA019587
HPA020857

GENE INFORMATION

Gene name

 UPF1 (HGNC Symbol)

Synonyms

 HUPF1, KIAA0221, NORF1, pNORF1, RENT1, smg-2

Description

 UPF1 regulator of nonsense transcripts homolog (yeast) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18831938 - 18868236

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005007 (version 83.38)

Entrez gene

 5976

UniProt

 Q92900 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92900

Antibodypedia

 UPF1 antibodies

PROTEIN BROWSER
UPF1-001
UPF1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UPF1-001
ENSP00000262803
ENST00000262803
Q92900 [Direct mapping]
Regulator of nonsense transcripts 1
A0A024R7L5 [Target identity:100%; Query identity:100%]
UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000785 [chromatin]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006406 [mRNA export from nucleus]
GO:0006449 [regulation of translational termination]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0035145 [exon-exon junction complex]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0071044 [histone mRNA catabolic process]
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 1118 aa
123 kDa 		No 0
UPF1-002
ENSP00000470142
ENST00000599848
Q92900 [Direct mapping]
Regulator of nonsense transcripts 1
A0A024R7L8 [Target identity:100%; Query identity:100%]
UPF1 regulator of nonsense transcripts homolog (Yeast), isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000785 [chromatin]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006406 [mRNA export from nucleus]
GO:0006449 [regulation of translational termination]
GO:0008270 [zinc ion binding]
GO:0009048 [dosage compensation by inactivation of X chromosome]
GO:0010467 [gene expression]
GO:0035145 [exon-exon junction complex]
GO:0044530 [supraspliceosomal complex]
GO:0044822 [poly(A) RNA binding]
GO:0071044 [histone mRNA catabolic process]
Show all
 1129 aa
124.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.