Expression of CCDC109B in cancer - Summary

GENERAL INFORMATION
Gene name	CCDC109B
Gene description	Coiled-coil domain containing 109B
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues, most abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA048776
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048776

GENE INFORMATION
Gene name	CCDC109B (HGNC Symbol)
Synonyms	FLJ20647
Description	Coiled-coil domain containing 109B (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q25
Chromosome location (bp)	109560205 - 109688726
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005059 (version 83.38)
Entrez gene	55013
UniProt	Q9NWR8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWR8
Antibodypedia	CCDC109B antibodies

PROTEIN BROWSER

CCDC109B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC109B-001 ENSP00000378145 ENST00000394650	Q9NWR8 [Direct mapping] Calcium uniporter regulatory subunit MCUb, mitochondrial Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006851 [mitochondrial calcium ion transport] GO:0019855 [calcium channel inhibitor activity] GO:0031224 [intrinsic component of membrane] GO:0031305 [integral component of mitochondrial inner membrane] GO:0034704 [calcium channel complex] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0051560 [mitochondrial calcium ion homeostasis] GO:1990246 [uniplex complex] Show all	336 aa 39.1 kDa	No	2