Cell atlas - DHX33 - The Human Protein Atlas

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DHX33

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	DHX33
Gene description	DEAH (Asp-Glu-Ala-His) box polypeptide 33
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA073875
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA073875	U-2 OS	Nucleoli
	HPA073875	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	DHX33 (HGNC Symbol)
Synonyms	DDX33, DKFZp762F2011, FLJ21972
Description	DEAH (Asp-Glu-Ala-His) box polypeptide 33 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	5440912 - 5469060
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005100 (version 83.38)
Entrez gene	56919
UniProt	Q9H6R0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6R0
Antibodypedia	DHX33 antibodies

PROTEIN BROWSER

DHX33-001	DHX33-003	DHX33-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHX33-001 ENSP00000225296 ENST00000225296	Q9H6R0 [Direct mapping] Putative ATP-dependent RNA helicase DHX33 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000182 [rDNA binding] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0033613 [activating transcription factor binding] GO:0044822 [poly(A) RNA binding] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] Show all	707 aa 78.9 kDa	No	0
DHX33-003 ENSP00000458925 ENST00000572490	I3L1L6 [Direct mapping] Putative ATP-dependent RNA helicase DHX33 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] Show all	617 aa 69.3 kDa	No	0
DHX33-004 ENSP00000413779 ENST00000433302	Q05BE5 [Direct mapping] DEAH (Asp-Glu-Ala-His) box polypeptide 33, isoform CRA_c; DHX33 protein; Putative ATP-dependent RNA helicase DHX33 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] Show all	483 aa 53.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.