Expression of ACSM3 in cancer - Summary - The Human Protein Atlas

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ACSM3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSM3
Gene description	Acyl-CoA synthetase medium-chain family member 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HEL, HMC-1, K-562)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041013
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041013

GENE INFORMATION
Gene name	ACSM3 (HGNC Symbol)
Synonyms	SA, SAH
Description	Acyl-CoA synthetase medium-chain family member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20610243 - 20797581
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005187 (version 83.38)
Entrez gene	6296
UniProt	Q53FZ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q53FZ2
Antibodypedia	ACSM3 antibodies

PROTEIN BROWSER

ACSM3-001	ACSM3-002	ACSM3-003	ACSM3-004	ACSM3-006	ACSM3-009	ACSM3-011	ACSM3-012	ACSM3-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSM3-001 ENSP00000289416 ENST00000289416	Q53FZ2 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0008217 [regulation of blood pressure] GO:0015645 [fatty acid ligase activity] GO:0042632 [cholesterol homeostasis] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	586 aa 66.2 kDa	No	0
ACSM3-002 ENSP00000394565 ENST00000440284	Q53FZ2 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0008217 [regulation of blood pressure] GO:0042632 [cholesterol homeostasis] GO:0046872 [metal ion binding] GO:0047760 [butyrate-CoA ligase activity] Show all	438 aa 49.5 kDa	No	0
ACSM3-003 ENSP00000456767 ENST00000562251	H3BSM0 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	582 aa 65.4 kDa	No	0
ACSM3-004 ENSP00000458068 ENST00000561795	H3BVD5 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	158 aa 18.3 kDa	No	0
ACSM3-006 ENSP00000457608 ENST00000569141	H3BUF2 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	136 aa 15.2 kDa	No	0
ACSM3-009 ENSP00000457926 ENST00000563914	H3BV29 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	235 aa 26.2 kDa	No	0
ACSM3-011 ENSP00000457158 ENST00000564701	H3BTG0 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.9 kDa	No	0
ACSM3-012 ENSP00000457003 ENST00000568235	H3BT38 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11.9 kDa	No	0
ACSM3-014 ENSP00000456055 ENST00000561584	H3BR33 [Direct mapping] Acyl-coenzyme A synthetase ACSM3, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 6.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.