Cell atlas - SPPL2B - The Human Protein Atlas

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SPPL2B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm
	Plasma membrane

Human cell
	Centrosome
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SPPL2B
Gene description	Signal peptide peptidase like 2B
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Plasma membrane (supported)
Additional location	In addition localized to the Centrosome (uncertain)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039292
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the centrosome.

Main location

Nucleoplasm (uncertain), Plasma membrane (supported)

Additional location

Centrosome (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039292	A549	Nucleoplasm
			Plasma membrane
			Centrosome
	HPA039292	SiHa	Nucleoplasm
			Plasma membrane
			Centrosome
	HPA039292	U-2 OS	Nucleoplasm
			Plasma membrane
			Actin filaments
			Centrosome

GENE INFORMATION
Gene name	SPPL2B (HGNC Symbol)
Synonyms	IMP4, KIAA1532, PSL1
Description	Signal peptide peptidase like 2B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2328615 - 2354806
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005206 (version 83.38)
Entrez gene	56928
UniProt	Q8TCT7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCT7
Antibodypedia	SPPL2B antibodies

PROTEIN BROWSER

SPPL2B-002	SPPL2B-004	SPPL2B-005	SPPL2B-013	SPPL2B-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPPL2B-002 ENSP00000478298 ENST00000613503	Q8TCT7 [Direct mapping] Signal peptide peptidase-like 2B Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006509 [membrane protein ectodomain proteolysis] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0033619 [membrane protein proteolysis] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0050776 [regulation of immune response] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	592 aa 64.6 kDa	Yes	9
SPPL2B-004 ENSP00000482362 ENST00000614794	A0A087WZ50 [Direct mapping] Signal peptide peptidase-like 2B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	291 aa 32.5 kDa	No	4
SPPL2B-005 ENSP00000480813 ENST00000618220	Q8TCT7 [Direct mapping] Signal peptide peptidase-like 2B Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006509 [membrane protein ectodomain proteolysis] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0033619 [membrane protein proteolysis] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0050776 [regulation of immune response] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	319 aa 35.3 kDa	Yes	4
SPPL2B-013 ENSP00000478510 ENST00000610743	Q8TCT7 [Direct mapping] Signal peptide peptidase-like 2B Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006509 [membrane protein ectodomain proteolysis] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0033619 [membrane protein proteolysis] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0050776 [regulation of immune response] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	511 aa 56.4 kDa	Yes	9
SPPL2B-014 ENSP00000477658 ENST00000612623	A0A087WT77 [Direct mapping] Signal peptide peptidase-like 2B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	166 aa 18.7 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.