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MSL3

GENERAL INFORMATION

Gene name

 MSL3

Gene description

 Male-specific lethal 3 homolog (Drosophila)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA034535 , HPA034536
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), head and neck cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Head and neck cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA034535
HPA034536

GENE INFORMATION

Gene name

 MSL3 (HGNC Symbol)

Synonyms

 MSL3L1

Description

 Male-specific lethal 3 homolog (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 11758159 - 11775753

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005302 (version 83.38)

Entrez gene

 10943

UniProt

 Q8N5Y2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N5Y2

Antibodypedia

 MSL3 antibodies

PROTEIN BROWSER
MSL3-001
MSL3-003
MSL3-004
MSL3-009
MSL3-010
MSL3-013
MSL3-201
MSL3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSL3-001
ENSP00000338078
ENST00000337339
Q8N5Y2 [Direct mapping]
Male-specific lethal 3 homolog
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0016575 [histone deacetylation]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0072487 [MSL complex]
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 416 aa
48 kDa 		No 0
MSL3-003
ENSP00000401809
ENST00000421368
C9JKR8 [Direct mapping]
Male-specific lethal 3 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016568 [chromatin modification]
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 224 aa
26 kDa 		No 0
MSL3-004
ENSP00000370068
ENST00000380692
A6NLU8 [Direct mapping]
Male-specific lethal 3 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016568 [chromatin modification]
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 196 aa
22.6 kDa 		No 0
MSL3-009
ENSP00000312244
ENST00000312196
Q8N5Y2 [Direct mapping]
Male-specific lethal 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0016575 [histone deacetylation]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0072487 [MSL complex]
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 521 aa
59.8 kDa 		No 0
MSL3-010
ENSP00000370069
ENST00000380693
Q8N5Y2 [Direct mapping]
Male-specific lethal 3 homolog
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0016575 [histone deacetylation]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0072487 [MSL complex]
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 355 aa
40.6 kDa 		No 0
MSL3-013
ENSP00000419976
ENST00000476743
C9JXM9 [Direct mapping]
Male-specific lethal 3 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 19 aa
2.3 kDa 		No 0
MSL3-201
ENSP00000354562
ENST00000361672
Q8N5Y2 [Direct mapping]
Male-specific lethal 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0016575 [histone deacetylation]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0072487 [MSL complex]
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 372 aa
42.7 kDa 		No 0
MSL3-202
ENSP00000381538
ENST00000398527
Q8N5Y2 [Direct mapping]
Male-specific lethal 3 homolog
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006342 [chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0016575 [histone deacetylation]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043968 [histone H2A acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0072487 [MSL complex]
Show all
 509 aa
58.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.