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IBTK

GENERAL INFORMATION

Gene name

 IBTK

Gene description

 Inhibitor of Bruton agammaglobulinemia tyrosine kinase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA023826 , HPA048438
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023826
HPA048438

GENE INFORMATION

Gene name

 IBTK (HGNC Symbol)

Synonyms

 BTBD26, BTKI, DKFZP564B116

Description

 Inhibitor of Bruton agammaglobulinemia tyrosine kinase (HGNC Symbol)

Entrez gene summary

 Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Chromosome

 6

Cytoband

 q14.1

Chromosome location (bp)

 82169983 - 82247754

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005700 (version 83.38)

Entrez gene

 25998

UniProt

 Q9P2D0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2D0

Antibodypedia

 IBTK antibodies

PROTEIN BROWSER
IBTK-001
IBTK-006
IBTK-007
IBTK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IBTK-001
ENSP00000305721
ENST00000306270
Q9P2D0 [Direct mapping]
Inhibitor of Bruton tyrosine kinase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0030292 [protein tyrosine kinase inhibitor activity]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
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 1353 aa
150.5 kDa 		No 0
IBTK-006
ENSP00000422762
ENST00000503631
E9PDR5 [Direct mapping]
Inhibitor of Bruton tyrosine kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 1152 aa
127.2 kDa 		No 0
IBTK-007
ENSP00000426405
ENST00000510291
E7EPI0 [Direct mapping]
Inhibitor of Bruton tyrosine kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 1338 aa
149 kDa 		No 0
IBTK-201
ENSP00000478891
ENST00000610980
E9PDR5 [Direct mapping]
Inhibitor of Bruton tyrosine kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
Show all
 1152 aa
127.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.