Tissue expression of ASB4 - Summary - The Human Protein Atlas

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ASB4

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ASB4
Gene description	Ankyrin repeat and SOCS box containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (adrenal gland, skeletal muscle)
GTEx:	Tissue enhanced (adrenal gland)
FANTOM5:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA055240
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	ASB4 (HGNC Symbol)
Synonyms	ASB-4
Description	Ankyrin repeat and SOCS box containing 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q21.3
Chromosome location (bp)	95478444 - 95540232
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000005981 (version 83.38)
Entrez gene	51666
UniProt	Q9Y574 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y574
Antibodypedia	ASB4 antibodies

PROTEIN BROWSER

ASB4-001	ASB4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB4-001 ENSP00000321388 ENST00000325885	Q9Y574 [Direct mapping] Ankyrin repeat and SOCS box protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0019899 [enzyme binding] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031466 [Cul5-RING ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035556 [intracellular signal transduction] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:2001214 [positive regulation of vasculogenesis] Show all	426 aa 48.2 kDa	No	0
ASB4-003 ENSP00000397070 ENST00000428113	Q9Y574 [Direct mapping] Ankyrin repeat and SOCS box protein 4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031466 [Cul5-RING ubiquitin ligase complex] GO:0035556 [intracellular signal transduction] GO:2001214 [positive regulation of vasculogenesis] Show all	349 aa 38.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.