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Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most malignant cells showed weak to moderate cytoplasmic positivity. A few hepatocellular carcinomas, ovarian, gastric, pancreatic and cervical cancers exhibited strong staining. Malignant gliomas and lymphomas along with several urothelial, testicular and lung cancers were negative.
GENE INFORMATION
Gene name
CRLF1 (HGNC Symbol)
Synonyms
CISS, CISS1, CLF, CLF-1
Description
Cytokine receptor-like factor 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)