Fields »
ABOUT
HELP
BLOG
OSBPL7

GENERAL INFORMATION

Gene name

 OSBPL7

Gene description

 Oxysterol binding protein-like 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HaCaT)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA036076 , HPA053083
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and renal cancer (unfavourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036076
HPA053083

GENE INFORMATION

Gene name

 OSBPL7 (HGNC Symbol)

Synonyms

 MGC71150, ORP7

Description

 Oxysterol binding protein-like 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 47807372 - 47821834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006025 (version 83.38)

Entrez gene

 114881

UniProt

 Q9BZF2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BZF2

Antibodypedia

 OSBPL7 antibodies

PROTEIN BROWSER
OSBPL7-001
OSBPL7-201
OSBPL7-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OSBPL7-001
ENSP00000007414
ENST00000007414
Q9BZF2 [Direct mapping]
Oxysterol-binding protein-related protein 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0015485 [cholesterol binding]
GO:0071397 [cellular response to cholesterol]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 842 aa
95.4 kDa 		No 0
OSBPL7-201
ENSP00000376295
ENST00000392507
Q9BZF2 [Direct mapping]
Oxysterol-binding protein-related protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0015485 [cholesterol binding]
GO:0071397 [cellular response to cholesterol]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 842 aa
95.4 kDa 		No 0
OSBPL7-202
ENSP00000479827
ENST00000613735
Q9BZF2 [Direct mapping]
Oxysterol-binding protein-related protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006869 [lipid transport]
GO:0015485 [cholesterol binding]
GO:0071397 [cellular response to cholesterol]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 357 aa
40.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.