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MAP3K14

GENERAL INFORMATION

Gene name

 MAP3K14

Gene description

 Mitogen-activated protein kinase kinase kinase 14

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAP3K14 (HGNC Symbol)

Synonyms

 FTDCR1B, HS, HSNIK, NIK

Description

 Mitogen-activated protein kinase kinase kinase 14 (HGNC Symbol)

Entrez gene summary

 This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45263121 - 45317040

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006062 (version 83.38)

Entrez gene

 9020

UniProt

 Q99558 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99558

Antibodypedia

 MAP3K14 antibodies

PROTEIN BROWSER
MAP3K14-001
MAP3K14-005
MAP3K14-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP3K14-001
ENSP00000478552
ENST00000344686
Q99558 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 14
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 947 aa
104 kDa 		No 0
MAP3K14-005
ENSP00000480974
ENST00000617331
A0A087WXF1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 14
Show all
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005737 [cytoplasm]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 157 aa
17.1 kDa 		No 0
MAP3K14-201
ENSP00000482657
ENST00000376926
Q99558 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 14
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 947 aa
104 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.