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MAP3K14

GENERAL INFORMATION

Gene name

 MAP3K14

Gene description

 Mitogen-activated protein kinase kinase kinase 14

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0510152025TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

 MAP3K14 (HGNC Symbol)

Synonyms

 FTDCR1B, HS, HSNIK, NIK

Description

 Mitogen-activated protein kinase kinase kinase 14 (HGNC Symbol)

Entrez gene summary

 This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45263121 - 45317040

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006062 (version 83.38)

Entrez gene

 9020

UniProt

 Q99558 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99558

Antibodypedia

 MAP3K14 antibodies

PROTEIN BROWSER
MAP3K14-001
MAP3K14-005
MAP3K14-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP3K14-001
ENSP00000478552
ENST00000344686
Q99558 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 14
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 947 aa
104 kDa 		No 0
MAP3K14-005
ENSP00000480974
ENST00000617331
A0A087WXF1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 14
Show all
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005737 [cytoplasm]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 157 aa
17.1 kDa 		No 0
MAP3K14-201
ENSP00000482657
ENST00000376926
Q99558 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 14
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 947 aa
104 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.