Expression of TMEM132A in cancer - Summary - The Human Protein Atlas

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TMEM132A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM132A
Gene description	Transmembrane protein 132A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in cerebral cortex and cerebellum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA051979
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051979

GENE INFORMATION
Gene name	TMEM132A (HGNC Symbol)
Synonyms	FLJ20539, GBP, HSPA5BP1
Description	Transmembrane protein 132A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60924463 - 60937159
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006118 (version 83.38)
Entrez gene	54972
UniProt	Q24JP5 (UniProt - Evidence at protein level)
neXtProt	NX_Q24JP5
Antibodypedia	TMEM132A antibodies

PROTEIN BROWSER

TMEM132A-001	TMEM132A-002	TMEM132A-006	TMEM132A-010	TMEM132A-015	TMEM132A-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM132A-001 ENSP00000405823 ENST00000453848	Q24JP5 [Direct mapping] Transmembrane protein 132A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1023 aa 110.1 kDa	Yes	1
TMEM132A-002 ENSP00000005286 ENST00000005286	Q24JP5 [Direct mapping] Transmembrane protein 132A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1024 aa 110.2 kDa	Yes	1
TMEM132A-006 ENSP00000437848 ENST00000540112	H0YFB3 [Direct mapping] Transmembrane protein 132A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 11.6 kDa	No	0
TMEM132A-010 ENSP00000442754 ENST00000544065	F5H765 [Direct mapping] Transmembrane protein 132A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.5 kDa	No	0
TMEM132A-015 ENSP00000439716 ENST00000535480	H0YFQ1 [Direct mapping] Transmembrane protein 132A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 10.9 kDa	No	0
TMEM132A-016 ENSP00000439717 ENST00000536409	H0YFQ2 [Direct mapping] Transmembrane protein 132A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 17 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.