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AP2B1

GENERAL INFORMATION

Gene name

 AP2B1

Gene description

 Adaptor-related protein complex 2, beta 1 subunit

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB017631
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB017631

GENE INFORMATION

Gene name

 AP2B1 (HGNC Symbol)

Synonyms

 ADTB2, CLAPB1

Description

 Adaptor-related protein complex 2, beta 1 subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 35578046 - 35726409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006125 (version 83.38)

Entrez gene

 163

UniProt

 P63010 (UniProt - Evidence at protein level)

neXtProt

 NX_P63010

Antibodypedia

 AP2B1 antibodies

PROTEIN BROWSER
«
AP2B1-001
AP2B1-004
AP2B1-005
AP2B1-006
AP2B1-007
AP2B1-009
AP2B1-010
AP2B1-011
AP2B1-018
AP2B1-019
AP2B1-021
AP2B1-022
AP2B1-201
AP2B1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP2B1-001
ENSP00000478471
ENST00000616784
A0A087WU93 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 663 aa
74.1 kDa 		No 0
AP2B1-004
ENSP00000481704
ENST00000621668
A0A087WYD1 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 639 aa
70.9 kDa 		No 0
AP2B1-005
ENSP00000482825
ENST00000612035
A0A087WZQ6 [Direct mapping]
AP-2 complex subunit beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 677 aa
75.3 kDa 		No 0
AP2B1-006
ENSP00000478115
ENST00000612116
A0A087WZQ6 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 677 aa
75.3 kDa 		No 0
AP2B1-007
ENSP00000479691
ENST00000614600
A0A087WZQ6 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 677 aa
75.3 kDa 		No 0
AP2B1-009
ENSP00000468183
ENST00000589774
K7ERB2 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 151 aa
17.2 kDa 		No 0
AP2B1-010
ENSP00000465357
ENST00000590432
K7EJX1 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 80 aa
9.2 kDa 		No 0
AP2B1-011
ENSP00000466812
ENST00000593014
K7EN71 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 132 aa
15.1 kDa 		No 0
AP2B1-018
ENSP00000466580
ENST00000587805
K7EMN7 [Direct mapping]
AP-2 complex subunit beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016192 [vesicle-mediated transport]
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 181 aa
20.4 kDa 		No 0
AP2B1-019
ENSP00000482315
ENST00000621914
P63010 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005048 [signal sequence binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030276 [clathrin binding]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 937 aa
104.6 kDa 		No 0
AP2B1-021
ENSP00000484708
ENST00000616681
A0A087X253 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
Show all
 913 aa
101.3 kDa 		No 0
AP2B1-022
ENSP00000483185
ENST00000610402
P63010 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005048 [signal sequence binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030276 [clathrin binding]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 951 aa
105.7 kDa 		No 0
AP2B1-201
ENSP00000482835
ENST00000618940
P63010 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003279 [cardiac septum development]
GO:0003281 [ventricular septum development]
GO:0005048 [signal sequence binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030118 [clathrin coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030276 [clathrin binding]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032403 [protein complex binding]
GO:0035615 [clathrin adaptor activity]
GO:0035904 [aorta development]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048268 [clathrin coat assembly]
GO:0050690 [regulation of defense response to virus by virus]
GO:0060976 [coronary vasculature development]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 951 aa
105.7 kDa 		No 0
AP2B1-202
ENSP00000487324
ENST00000628168
K7EKZ5 [Direct mapping]
AP-2 complex subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016192 [vesicle-mediated transport]
Show all
 63 aa
7.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.