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TAC1

GENERAL INFORMATION

Gene name

 TAC1

Gene description

 Tachykinin, precursor 1

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (U-266/70)
HPA (normal tissue):Tissue enhanced (cerebral cortex, spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA014429 , CAB004588
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA014429
CAB004588

GENE INFORMATION

Gene name

 TAC1 (HGNC Symbol)

Synonyms

 NKNA, NPK, TAC2

Description

 Tachykinin, precursor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 97731908 - 97740472

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006128 (version 83.38)

Entrez gene

 6863

UniProt

 P20366 (UniProt - Evidence at protein level)

neXtProt

 NX_P20366

Antibodypedia

 TAC1 antibodies

PROTEIN BROWSER
TAC1-001
TAC1-002
TAC1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAC1-001
ENSP00000321106
ENST00000319273
P20366 [Direct mapping]
Protachykinin-1 Substance P Neurokinin A Neuropeptide K Neuropeptide gamma C-terminal-flanking peptide
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0001878 [response to yeast]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007217 [tachykinin receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0007320 [insemination]
GO:0007616 [long-term memory]
GO:0008217 [regulation of blood pressure]
GO:0008306 [associative learning]
GO:0009582 [detection of abiotic stimulus]
GO:0009725 [response to hormone]
GO:0010459 [negative regulation of heart rate]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0019233 [sensory perception of pain]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0030424 [axon]
GO:0031835 [substance P receptor binding]
GO:0032224 [positive regulation of synaptic transmission, cholinergic]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0043025 [neuronal cell body]
GO:0043278 [response to morphine]
GO:0045087 [innate immune response]
GO:0045760 [positive regulation of action potential]
GO:0045778 [positive regulation of ossification]
GO:0046878 [positive regulation of saliva secretion]
GO:0048265 [response to pain]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051496 [positive regulation of stress fiber assembly]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2000854 [positive regulation of corticosterone secretion]
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 129 aa
15 kDa 		Yes 0
TAC1-002
ENSP00000289574
ENST00000346867
P20366 [Direct mapping]
Protachykinin-1 Substance P Neurokinin A Neuropeptide K Neuropeptide gamma C-terminal-flanking peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001878 [response to yeast]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007217 [tachykinin receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0007320 [insemination]
GO:0009582 [detection of abiotic stimulus]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
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 114 aa
13.3 kDa 		Yes 0
TAC1-003
ENSP00000289576
ENST00000350485
P20366 [Direct mapping]
Protachykinin-1 Substance P Neurokinin A Neuropeptide K Neuropeptide gamma C-terminal-flanking peptide
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001878 [response to yeast]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007217 [tachykinin receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0007320 [insemination]
GO:0009582 [detection of abiotic stimulus]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
Show all
 111 aa
13 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.