Expression of MAP3K9 in cancer - Summary - The Human Protein Atlas

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MAP3K9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP3K9
Gene description	Mitogen-activated protein kinase kinase kinase 9
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA000942
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000942

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Malignant gliomas, lung, testis and hepatocellular cancers showed moderate cytoplasmic with additional nuclear positivity. Remaining malignancies were weakly stained or negative.

GENE INFORMATION
Gene name	MAP3K9 (HGNC Symbol)
Synonyms	MEKK9, MLK1, PRKE1
Description	Mitogen-activated protein kinase kinase kinase 9 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.2
Chromosome location (bp)	70722526 - 70809534
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006432 (version 83.38)
Entrez gene	4293
UniProt	P80192 (UniProt - Evidence at protein level)
neXtProt	NX_P80192
Antibodypedia	MAP3K9 antibodies

PROTEIN BROWSER

MAP3K9-001	MAP3K9-002	MAP3K9-003	MAP3K9-004	MAP3K9-005	MAP3K9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K9-001 ENSP00000451612 ENST00000554752	P80192 [Direct mapping] Mitogen-activated protein kinase kinase kinase 9 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004706 [JUN kinase kinase kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007256 [activation of JNKK activity] GO:0007257 [activation of JUN kinase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] Show all	1104 aa 121.9 kDa	Yes	0
MAP3K9-002 ENSP00000451263 ENST00000555993	P80192 [Direct mapping] Mitogen-activated protein kinase kinase kinase 9 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004706 [JUN kinase kinase kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007256 [activation of JNKK activity] GO:0007257 [activation of JUN kinase activity] GO:0008219 [cell death] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0046777 [protein autophosphorylation] Show all	1118 aa 123.4 kDa	Yes	0
MAP3K9-003 ENSP00000370649 ENST00000381250	J3KPI6 [Direct mapping] Mitogen-activated protein kinase kinase kinase 9 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	1081 aa 119.4 kDa	Yes	0
MAP3K9-004 ENSP00000451921 ENST00000554146	G3V4P9 [Direct mapping] Mitogen-activated protein kinase kinase kinase 9 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	832 aa 92.4 kDa	No	0
MAP3K9-005 ENSP00000451038 ENST00000553414	G3V347 [Direct mapping] Mitogen-activated protein kinase kinase kinase 9 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	837 aa 92.8 kDa	No	0
MAP3K9-201 ENSP00000480011 ENST00000611979	A0A087WW79 [Direct mapping] Mitogen-activated protein kinase kinase kinase 9 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	880 aa 97.7 kDa	No	0

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