Expression of KDM7A in cancer - Summary

GENERAL INFORMATION
Gene name	KDM7A
Gene description	Lysine (K)-specific demethylase 7A
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with additional cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data.
Reliability score	Uncertain based on 1 antibody. HPA012114
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA012114

GENE INFORMATION
Gene name	KDM7A (HGNC Symbol)
Synonyms	JHDM1D, KIAA1718
Description	Lysine (K)-specific demethylase 7A (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q34
Chromosome location (bp)	140084746 - 140177035
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006459 (version 83.38)
Entrez gene	80853
UniProt	Q6ZMT4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMT4
Antibodypedia	KDM7A antibodies

PROTEIN BROWSER

KDM7A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KDM7A-001 ENSP00000380692 ENST00000397560	Q6ZMT4 [Direct mapping] Lysine-specific demethylase 7A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0030901 [midbrain development] GO:0032454 [histone demethylase activity (H3-K9 specific)] GO:0033169 [histone H3-K9 demethylation] GO:0035064 [methylated histone binding] GO:0035574 [histone H4-K20 demethylation] GO:0035575 [histone demethylase activity (H4-K20 specific)] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0051864 [histone demethylase activity (H3-K36 specific)] GO:0055114 [oxidation-reduction process] GO:0070544 [histone H3-K36 demethylation] GO:0071557 [histone H3-K27 demethylation] GO:0071558 [histone demethylase activity (H3-K27 specific)] Show all	941 aa 106.6 kDa	Yes	0