Fields »
ABOUT
HELP
BLOG
ALDH3B1

GENERAL INFORMATION

Gene name

 ALDH3B1

Gene description

 Aldehyde dehydrogenase 3 family, member B1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, CAPAN-2)
HPA (normal tissue):Tissue enhanced (fallopian tube, lung)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in ciliated cells of respiratory epithelia and fallopian tube.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Respiratory epithelium should be compared to the lung RNAseq values.

Reliability score

 Uncertain based on 1 antibody.
HPA038525
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and pancreatic cancer (unfavourable).
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA038525

GENE INFORMATION

Gene name

 ALDH3B1 (HGNC Symbol)

Synonyms

 ALDH7

Description

 Aldehyde dehydrogenase 3 family, member B1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 68008578 - 68029282

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006534 (version 83.38)

Entrez gene

 221

UniProt

 P43353 (UniProt - Evidence at protein level)

neXtProt

 NX_P43353

Antibodypedia

 ALDH3B1 antibodies

PROTEIN BROWSER
ALDH3B1-001
ALDH3B1-002
ALDH3B1-004
ALDH3B1-006
ALDH3B1-007
ALDH3B1-009
ALDH3B1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH3B1-001
ENSP00000473990
ENST00000342456
P43353 [Direct mapping]
Aldehyde dehydrogenase family 3 member B1
A0A024R5D8 [Target identity:100%; Query identity:100%]
Aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031982 [vesicle]
GO:0034599 [cellular response to oxidative stress]
GO:0044281 [small molecule metabolic process]
GO:0046185 [aldehyde catabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 468 aa
51.8 kDa 		No 0
ALDH3B1-002
ENSP00000478486
ENST00000614849
P43353 [Direct mapping]
Aldehyde dehydrogenase family 3 member B1
A0A024R5D8 [Target identity:100%; Query identity:100%]
Aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031982 [vesicle]
GO:0034599 [cellular response to oxidative stress]
GO:0044281 [small molecule metabolic process]
GO:0046185 [aldehyde catabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 468 aa
51.8 kDa 		No 0
ALDH3B1-004
ENSP00000481604
ENST00000617288
P43353 [Direct mapping]
Aldehyde dehydrogenase family 3 member B1
A0A024R5K0 [Target identity:100%; Query identity:100%]
Aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031982 [vesicle]
GO:0034599 [cellular response to oxidative stress]
GO:0044281 [small molecule metabolic process]
GO:0046185 [aldehyde catabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 431 aa
47.7 kDa 		No 0
ALDH3B1-006
ENSP00000484901
ENST00000612297
A0A087X2D4 [Direct mapping]
Aldehyde dehydrogenase family 3 member B1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 351 aa
38.9 kDa 		No 0
ALDH3B1-007
ENSP00000478380
ENST00000527514
A0A087WU54 [Direct mapping]
Aldehyde dehydrogenase family 3 member B1
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 71 aa
8.2 kDa 		No 0
ALDH3B1-009
ENSP00000483988
ENST00000617449
A0A087X192 [Direct mapping]
Aldehyde dehydrogenase family 3 member B1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 211 aa
23.3 kDa 		No 0
ALDH3B1-201
ENSP00000479948
ENST00000615463
Q9BUJ8 [Direct mapping]
ALDH3B1 protein; Aldehyde dehydrogenase family 3 member B1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 230 aa
25.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.