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CCL26

GENERAL INFORMATION

Gene name

 CCL26

Gene description

 Chemokine (C-C motif) ligand 26

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (PC-3, U-2 OS)
HPA (normal tissue):Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CCL26 (HGNC Symbol)

Synonyms

 eotaxin-3, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1

Description

 Chemokine (C-C motif) ligand 26 (HGNC Symbol)

Entrez gene summary

 This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 75769533 - 75789896

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000006606 (version 83.38)

Entrez gene

 10344

UniProt

 Q9Y258 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y258

Antibodypedia

 CCL26 antibodies

PROTEIN BROWSER
CCL26-001
CCL26-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL26-001
ENSP00000005180
ENST00000005180
Q9Y258 [Direct mapping]
C-C motif chemokine 26
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0030335 [positive regulation of cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 94 aa
10.6 kDa 		Yes 0
CCL26-002
ENSP00000378365
ENST00000394905
Q9Y258 [Direct mapping]
C-C motif chemokine 26
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0030335 [positive regulation of cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
Show all
 94 aa
10.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.