Tissue expression of ELAC2 - Summary - The Human Protein Atlas

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ELAC2

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ELAC2
Gene description	ElaC ribonuclease Z 2
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression, additional cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA019535
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ELAC2 (HGNC Symbol)
Synonyms	FLJ10530, HPC2
Description	ElaC ribonuclease Z 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	17
Cytoband	p12
Chromosome location (bp)	12992391 - 13018187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006744 (version 83.38)
Entrez gene	60528
UniProt	Q9BQ52 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ52
Antibodypedia	ELAC2 antibodies

PROTEIN BROWSER

ELAC2-001	ELAC2-002	ELAC2-007	ELAC2-012	ELAC2-013	ELAC2-015	ELAC2-016	ELAC2-017	ELAC2-020	ELAC2-021	ELAC2-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELAC2-001 ENSP00000337445 ENST00000338034	Q9BQ52 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0042645 [mitochondrial nucleoid] GO:0042781 [3'-tRNA processing endoribonuclease activity] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072684 [mitochondrial tRNA 3'-trailer cleavage, endonucleolytic] Show all	826 aa 92.2 kDa	No	0
ELAC2-002 ENSP00000379291 ENST00000395962	G5E9D5 [Direct mapping] ElaC homolog 2 (E. coli), isoform CRA_a; Zinc phosphodiesterase ELAC protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	807 aa 90 kDa	No	0
ELAC2-007 ENSP00000406192 ENST00000446899	H7C2I4 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	286 aa 31.7 kDa	No	0
ELAC2-012 ENSP00000405223 ENST00000426905	Q9BQ52 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008033 [tRNA processing] GO:0010467 [gene expression] GO:0042781 [3'-tRNA processing endoribonuclease activity] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072684 [mitochondrial tRNA 3'-trailer cleavage, endonucleolytic] Show all	786 aa 87.6 kDa	No	0
ELAC2-013 ENSP00000463740 ENST00000584650	E7ES68 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	626 aa 70.1 kDa	No	0
ELAC2-015 ENSP00000477482 ENST00000578071	V9GZ72 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008033 [tRNA processing] GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	158 aa 17.5 kDa	No	0
ELAC2-016 ENSP00000464358 ENST00000583371	J3QRS2 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	122 aa 13.9 kDa	No	0
ELAC2-017 ENSP00000463321 ENST00000581499	J3QL08 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	132 aa 15 kDa	No	0
ELAC2-020 ENSP00000463594 ENST00000580504	J3QLK4 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	148 aa 16.5 kDa	No	0
ELAC2-021 ENSP00000477044 ENST00000609101	V9GYS7 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	242 aa 26.8 kDa	No	0
ELAC2-022 ENSP00000477093 ENST00000609757	V9GYU5 [Direct mapping] Zinc phosphodiesterase ELAC protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0034414 [tRNA 3'-trailer cleavage, endonucleolytic] GO:0042781 [3'-tRNA processing endoribonuclease activity] Show all	124 aa 14.1 kDa	No	0

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