Cell atlas - PNPLA4 - The Human Protein Atlas

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PNPLA4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PNPLA4
Gene description	Patatin-like phospholipase domain containing 4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PNPLA4 (HGNC Symbol)
Synonyms	DXS1283E, GS2, iPLA2eta
Description	Patatin-like phospholipase domain containing 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010]
Chromosome	X
Cytoband	p22.31
Chromosome location (bp)	7898247 - 7927739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000006757 (version 83.38)
Entrez gene	8228
UniProt	P41247 (UniProt - Evidence at transcript level)
neXtProt	NX_P41247
Antibodypedia	PNPLA4 antibodies

PROTEIN BROWSER

PNPLA4-002	PNPLA4-003	PNPLA4-201	PNPLA4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNPLA4-002 ENSP00000406698 ENST00000442940	C9IZF6 [Direct mapping] Patatin-like phospholipase domain-containing protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] Show all	190 aa 20.6 kDa	Yes	0
PNPLA4-003 ENSP00000370430 ENST00000381042	P41247 [Direct mapping] Patatin-like phospholipase domain-containing protein 4 A0A024RBU8 [Target identity:100%; Query identity:100%] Patatin-like phospholipase domain containing 4, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0006629 [lipid metabolic process] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016042 [lipid catabolic process] Show all	253 aa 28 kDa	Yes	0
PNPLA4-201 ENSP00000415245 ENST00000444736	P41247 [Direct mapping] Patatin-like phospholipase domain-containing protein 4 A0A024RBU8 [Target identity:100%; Query identity:100%] Patatin-like phospholipase domain containing 4, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0006629 [lipid metabolic process] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016042 [lipid catabolic process] Show all	253 aa 28 kDa	Yes	0
PNPLA4-202 ENSP00000443157 ENST00000537427	P41247 [Direct mapping] Patatin-like phospholipase domain-containing protein 4 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0006629 [lipid metabolic process] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016042 [lipid catabolic process] Show all	166 aa 18.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.