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MARK4

GENERAL INFORMATION

Gene name

 MARK4

Gene description

 MAP/microtubule affinity-regulating kinase 4

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. Strong positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039186
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and head and neck cancer (unfavourable).
Endometrial cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039186

GENE INFORMATION

Gene name

 MARK4 (HGNC Symbol)

Synonyms

 FLJ90097, KIAA1860, MARKL1, Nbla00650, PAR-1D

Description

 MAP/microtubule affinity-regulating kinase 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45079288 - 45305283

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007047 (version 83.38)

Entrez gene

 57787

UniProt

 Q96L34 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96L34

Antibodypedia

 MARK4 antibodies

PROTEIN BROWSER
MARK4-001
MARK4-002
MARK4-006
MARK4-010
MARK4-201
MARK4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARK4-001
ENSP00000262891
ENST00000262891
Q96L34 [Direct mapping]
MAP/microtubule affinity-regulating kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization]
GO:0001578 [microtubule bundle formation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007399 [nervous system development]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0036064 [ciliary basal body]
GO:0043005 [neuron projection]
GO:0043015 [gamma-tubulin binding]
GO:0043068 [positive regulation of programmed cell death]
GO:0043130 [ubiquitin binding]
GO:0050321 [tau-protein kinase activity]
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 752 aa
82.5 kDa 		No 0
MARK4-002
ENSP00000300843
ENST00000300843
Q96L34 [Direct mapping]
MAP/microtubule affinity-regulating kinase 4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001578 [microtubule bundle formation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007399 [nervous system development]
GO:0008017 [microtubule binding]
GO:0015630 [microtubule cytoskeleton]
GO:0036064 [ciliary basal body]
GO:0043005 [neuron projection]
GO:0043015 [gamma-tubulin binding]
GO:0043068 [positive regulation of programmed cell death]
GO:0043130 [ubiquitin binding]
GO:0050321 [tau-protein kinase activity]
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 688 aa
75.3 kDa 		No 0
MARK4-006
ENSP00000465613
ENST00000590909
K7EKG8 [Direct mapping]
MAP/microtubule affinity-regulating kinase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 74 aa
8.7 kDa 		No 0
MARK4-010
ENSP00000465414
ENST00000587566
K7EK17 [Direct mapping]
MAP/microtubule affinity-regulating kinase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 62 aa
7.2 kDa 		No 0
MARK4-201
ENSP00000480702
ENST00000620044
Q6IPE9 [Direct mapping]
MAP/microtubule affinity-regulating kinase 4; MARK4 protein
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 97 aa
10.5 kDa 		No 1
MARK4-202
ENSP00000484974
ENST00000622871
Q96GZ3 [Direct mapping]
MAP/microtubule affinity-regulating kinase 4; MARK4 protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000930 [gamma-tubulin complex]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0008284 [positive regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0043015 [gamma-tubulin binding]
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 79 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.