Expression of CEACAM21 in cancer - Summary - The Human Protein Atlas

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CEACAM21

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEACAM21
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 21
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HMC-1, Karpas-707, U-266/70, U-937)
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA043411
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043411

GENE INFORMATION
Gene name	CEACAM21 (HGNC Symbol)
Synonyms	FLJ13540, R29124_1
Description	Carcinoembryonic antigen-related cell adhesion molecule 21 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41549518 - 41586844
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000007129 (version 83.38)
Entrez gene	90273
UniProt	Q3KPI0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3KPI0
Antibodypedia	CEACAM21 antibodies

PROTEIN BROWSER

CEACAM21-002	CEACAM21-004	CEACAM21-005	CEACAM21-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM21-002 ENSP00000384380 ENST00000407170	A0A0B4J1W4 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 21 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	165 aa 18 kDa	No	1
CEACAM21-004 ENSP00000187608 ENST00000187608	Q3KPI0 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 21 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	292 aa 32.3 kDa	No	1
CEACAM21-005 ENSP00000385739 ENST00000401445	Q3KPI0 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 21 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	293 aa 32.4 kDa	No	1
CEACAM21-010 ENSP00000488260 ENST00000632983		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] Show all	95 aa 10.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.