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Weak to moderate cytoplasmic staining was observed in most malignancies. A few cases of testis and urothelial cancers were strongly stained while several liver, renal and prostate cancers were negative.
A majority of malignant cells showed weak to moderate cytoplasmic immunoreactivity. Several malignancies, for example endometrial and urothelial cancers, showed both cytoplasmic and nuclear staining. Testicular cancer, several cases of malignant lymphomas and a few cases of colorectal, endometrial, renal and pancreatic cancer were strongly stained.
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009]