Tissue expression of CEACAM7 - Summary - The Human Protein Atlas

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CEACAM7

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CEACAM7
Gene description	Carcinoembryonic antigen-related cell adhesion molecule 7
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (colon, rectum)
GTEx:	Tissue enriched (colon)
FANTOM5:	Tissue enhanced (appendix, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Expression in luminal membranes of colon and rectum

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA069621
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, rectum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (colon)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION
Gene name	CEACAM7 (HGNC Symbol)
Synonyms	CEA, CGM2
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41673307 - 41706976
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000007306 (version 83.38)
Entrez gene	1087
UniProt	Q14002 (UniProt - Evidence at protein level)
neXtProt	NX_Q14002
Antibodypedia	CEACAM7 antibodies

PROTEIN BROWSER

CEACAM7-001	CEACAM7-002	CEACAM7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEACAM7-001 ENSP00000006724 ENST00000006724	Q14002 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0031225 [anchored component of membrane] Show all	265 aa 29.3 kDa	Yes	1
CEACAM7-002 ENSP00000385932 ENST00000401731	Q14002 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0031225 [anchored component of membrane] Show all	265 aa 29.3 kDa	Yes	1
CEACAM7-003 ENSP00000469597 ENST00000602225	A0A0A0MTT6 [Direct mapping] Carcinoembryonic antigen-related cell adhesion molecule 7 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	172 aa 19 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.