Expression of ST7L in cancer - Summary - The Human Protein Atlas

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ST7L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ST7L
Gene description	Suppression of tumorigenicity 7 like
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA042324
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable), colorectal cancer (favourable), melanoma (unfavourable) and endometrial cancer (unfavourable).
Ovarian cancer p<0.001 Colorectal cancer p<0.001 Melanoma p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042324

GENE INFORMATION
Gene name	ST7L (HGNC Symbol)
Synonyms	FAM4B, FLJ20284, ST7R, STLR
Description	Suppression of tumorigenicity 7 like (HGNC Symbol)
Entrez gene summary	This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	112523518 - 112620825
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000007341 (version 83.38)
Entrez gene	54879
UniProt	Q8TDW4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDW4
Antibodypedia	ST7L antibodies

PROTEIN BROWSER

ST7L-001	ST7L-002	ST7L-003	ST7L-004	ST7L-008	ST7L-011	ST7L-020	ST7L-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST7L-001 ENSP00000350734 ENST00000358039	Q8TDW4 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] Show all	575 aa 64.8 kDa	No	3
ST7L-002 ENSP00000417140 ENST00000490067	Q8TDW4 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] Show all	558 aa 62.9 kDa	No	3
ST7L-003 ENSP00000353972 ENST00000360743	Q8TDW4 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] Show all	544 aa 61.1 kDa	No	3
ST7L-004 ENSP00000345312 ENST00000343210	Q8TDW4 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] Show all	555 aa 62.7 kDa	No	3
ST7L-008 ENSP00000358680 ENST00000369666	Q8TDW4 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] Show all	538 aa 60.8 kDa	No	3
ST7L-011 ENSP00000358683 ENST00000369669	Q8TDW4 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030308 [negative regulation of cell growth] Show all	392 aa 44.7 kDa	No	1
ST7L-020 ENSP00000358678 ENST00000369664	Q5TEH7 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	229 aa 26.5 kDa	No	1
ST7L-024 ENSP00000413718 ENST00000418497	H0Y7M0 [Direct mapping] Suppressor of tumorigenicity 7 protein-like Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		287 aa 33.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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