Tissue expression of TKTL1 - Summary - The Human Protein Atlas

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TKTL1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TKTL1
Gene description	Transketolase-like 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in spermatogonia.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA000505 , CAB032191
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	TKTL1 (HGNC Symbol)
Synonyms	TKR, TKT2
Description	Transketolase-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	154295671 - 154330350
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000007350 (version 83.38)
Entrez gene	8277
UniProt	P51854 (UniProt - Evidence at protein level)
neXtProt	NX_P51854
Antibodypedia	TKTL1 antibodies

PROTEIN BROWSER

TKTL1-001	TKTL1-002	TKTL1-005	TKTL1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TKTL1-001 ENSP00000358928 ENST00000369912	P51854 [Direct mapping] Transketolase-like protein 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004802 [transketolase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006007 [glucose catabolic process] GO:0006772 [thiamine metabolic process] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	540 aa 59.3 kDa	No	0
TKTL1-002 ENSP00000358931 ENST00000369915	P51854 [Direct mapping] Transketolase-like protein 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004802 [transketolase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006007 [glucose catabolic process] GO:0006772 [thiamine metabolic process] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	596 aa 65.3 kDa	No	0
TKTL1-005 ENSP00000401111 ENST00000426989	A2ID95 [Direct mapping] Transketolase-like 1; Transketolase-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		197 aa 22 kDa	No	0
TKTL1-006 ENSP00000416552 ENST00000426203	H0Y808 [Direct mapping] Transketolase-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 19.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.