Cell atlas - CACNA2D2 - The Human Protein Atlas

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CACNA2D2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CACNA2D2
Gene description	Calcium channel, voltage-dependent, alpha 2/delta subunit 2
Protein class	FDA approved drug targets Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071829
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071829	HEK 293	Vesicles
	HPA071829	SH-SY5Y	Vesicles	Intensity

GENE INFORMATION
Gene name	CACNA2D2 (HGNC Symbol)
Synonyms	KIAA0558
Description	Calcium channel, voltage-dependent, alpha 2/delta subunit 2 (HGNC Symbol)
Entrez gene summary	Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	50362799 - 50504244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000007402 (version 83.38)
Entrez gene	9254
UniProt	Q9NY47 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY47
Antibodypedia	CACNA2D2 antibodies

PROTEIN BROWSER

CACNA2D2-001	CACNA2D2-002	CACNA2D2-003	CACNA2D2-005	CACNA2D2-007	CACNA2D2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA2D2-001 ENSP00000390329 ENST00000424201	Q9NY47 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1143 aa 129.1 kDa	No	0
CACNA2D2-002 ENSP00000266039 ENST00000266039	Q9NY47 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1145 aa 129.3 kDa	No	0
CACNA2D2-003 ENSP00000354228 ENST00000360963	Q9NY47 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0034765 [regulation of ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1076 aa 122.1 kDa	No	0
CACNA2D2-005 ENSP00000418081 ENST00000479441	Q9NY47 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005246 [calcium channel regulator activity] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0007528 [neuromuscular junction development] GO:0034765 [regulation of ion transmembrane transport] GO:0040014 [regulation of multicellular organism growth] GO:0044281 [small molecule metabolic process] GO:0046622 [positive regulation of organ growth] GO:0046872 [metal ion binding] GO:0048747 [muscle fiber development] GO:0050796 [regulation of insulin secretion] GO:0051924 [regulation of calcium ion transport] GO:0060024 [rhythmic synaptic transmission] GO:0070588 [calcium ion transmembrane transport] Show all	1150 aa 129.8 kDa	No	0
CACNA2D2-007 ENSP00000407393 ENST00000423994	C9JVC9 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005891 [voltage-gated calcium channel complex] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1153 aa 130.1 kDa	No	0
CACNA2D2-008 ENSP00000404631 ENST00000429770	C9JE82 [Direct mapping] Voltage-dependent calcium channel subunit alpha-2/delta-2 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005891 [voltage-gated calcium channel complex] GO:0051924 [regulation of calcium ion transport] GO:0070588 [calcium ion transmembrane transport] Show all	1144 aa 129.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.