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NOX1

GENERAL INFORMATION

Gene name

 NOX1

Gene description

 NADPH oxidase 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (colorectal cancer)
HPA (cell line):Cell line enriched (CACO-2)
HPA (normal tissue):Group enriched (colon, rectum)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (colorectal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NOX1 (HGNC Symbol)

Synonyms

 GP91-2, MOX1, NOH-1, NOH1

Description

 NADPH oxidase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 X

Cytoband

 q22.1

Chromosome location (bp)

 100843324 - 100874345

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007952 (version 83.38)

Entrez gene

 27035

UniProt

 Q9Y5S8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5S8

Antibodypedia

 NOX1 antibodies

PROTEIN BROWSER
NOX1-001
NOX1-002
NOX1-003
NOX1-004
NOX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOX1-001
ENSP00000362057
ENST00000372966
Q9Y5S8 [Direct mapping]
NADPH oxidase 1
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Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006739 [NADP metabolic process]
GO:0006801 [superoxide metabolic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016477 [cell migration]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0030171 [voltage-gated proton channel activity]
GO:0030198 [extracellular matrix organization]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042554 [superoxide anion generation]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0043020 [NADPH oxidase complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045730 [respiratory burst]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0048365 [Rac GTPase binding]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050661 [NADP binding]
GO:0051454 [intracellular pH elevation]
GO:0055114 [oxidation-reduction process]
GO:0071438 [invadopodium membrane]
GO:0071455 [cellular response to hyperoxia]
GO:0072592 [oxygen metabolic process]
GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990451 [cellular stress response to acidic pH]
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 564 aa
64.9 kDa 		No 7
NOX1-002
ENSP00000362055
ENST00000372964
Q5H9D4 [Direct mapping]
NADPH oxidase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 192 aa
22 kDa 		No 4
NOX1-003
ENSP00000217885
ENST00000217885
Q9Y5S8 [Direct mapping]
NADPH oxidase 1
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Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006739 [NADP metabolic process]
GO:0006801 [superoxide metabolic process]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016477 [cell migration]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0030171 [voltage-gated proton channel activity]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042554 [superoxide anion generation]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0043020 [NADPH oxidase complex]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045730 [respiratory burst]
GO:0046872 [metal ion binding]
GO:0048365 [Rac GTPase binding]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050661 [NADP binding]
GO:0051454 [intracellular pH elevation]
GO:0055114 [oxidation-reduction process]
GO:0071438 [invadopodium membrane]
GO:1990451 [cellular stress response to acidic pH]
Show all
 515 aa
59 kDa 		No 7
NOX1-004
ENSP00000396992
ENST00000427768
H0Y581 [Direct mapping]
NADPH oxidase 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 175 aa
20.3 kDa 		No 0
NOX1-201
ENSP00000362051
ENST00000372960
A6NGA6 [Direct mapping]
NADPH oxidase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 527 aa
60.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.