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E2F2

GENERAL INFORMATION

Gene name

 E2F2

Gene description

 E2F transcription factor 2

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining.

Reliability score

 Uncertain based on 1 antibody.
CAB016313
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016313

GENE INFORMATION

Gene name

 E2F2 (HGNC Symbol)

Synonyms

 E2F-2

Description

 E2F transcription factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 23506430 - 23531220

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000007968 (version 83.38)

Entrez gene

 1870

UniProt

 Q14209 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14209

Antibodypedia

 E2F2 antibodies

PROTEIN BROWSER
E2F2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
E2F2-001
ENSP00000355249
ENST00000361729
Q14209 [Direct mapping]
Transcription factor E2F2
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000278 [mitotic cell cycle]
GO:0001047 [core promoter binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0051726 [regulation of cell cycle]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:1990086 [lens fiber cell apoptotic process]
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 437 aa
47.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.