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SYN1

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GENERAL INFORMATION

Gene name

 SYN1

Gene description

 Synapsin I

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SCLC-21H, NTERA-2, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, NTERA-2, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SYN1

Synonyms

Description

 Synapsin I (HGNC Symbol)

Entrez gene summary

 This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

Chromosome location (bp)

 47571898 - 47619853

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000008056 (version 83.38)

Entrez gene

 6853

UniProt

 P17600 (UniProt - Evidence at protein level)

neXtProt

 NX_P17600

Antibodypedia

 SYN1 antibodies

PROTEIN BROWSER
SYN1-001
SYN1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYN1-001
ENSP00000295987
ENST00000295987
P17600 [Direct mapping]
Synapsin-1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0003824 [catalytic activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030672 [synaptic vesicle membrane]
GO:0043195 [terminal bouton]
GO:0043209 [myelin sheath]
GO:0043229 [intracellular organelle]
GO:0045202 [synapse]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048306 [calcium-dependent protein binding]
GO:0048786 [presynaptic active zone]
GO:2000300 [regulation of synaptic vesicle exocytosis]
Show all
 705 aa
74.1 kDa 		No 0
SYN1-002
ENSP00000343206
ENST00000340666
P17600 [Direct mapping]
Synapsin-1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0003824 [catalytic activity]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0046928 [regulation of neurotransmitter secretion]
GO:2000300 [regulation of synaptic vesicle exocytosis]
Show all
 669 aa
70 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.