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CDK11A

GENERAL INFORMATION

Gene name

 CDK11A

Gene description

 Cyclin-dependent kinase 11A

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression which in cases was combined with expression in cytoplasm.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA025061 , CAB010467
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA025061
CAB010467

GENE INFORMATION

Gene name

 CDK11A (HGNC Symbol)

Synonyms

 CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE

Description

 Cyclin-dependent kinase 11A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1702730 - 1724324

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000008128 (version 83.38)

Entrez gene

 728642

UniProt

 Q9UQ88 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQ88

Antibodypedia

 CDK11A antibodies

PROTEIN BROWSER
CDK11A-001
CDK11A-003
CDK11A-004
CDK11A-005
CDK11A-007
CDK11A-008
CDK11A-011
CDK11A-027

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK11A-001
ENSP00000384442
ENST00000404249
Q9UQ88 [Direct mapping]
Cyclin-dependent kinase 11A
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0050684 [regulation of mRNA processing]
GO:0051726 [regulation of cell cycle]
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 780 aa
91 kDa 		No 0
CDK11A-003
ENSP00000350403
ENST00000357760
Q5QPR3 [Direct mapping]
Cyclin-dependent kinase 11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 779 aa
91 kDa 		No 0
CDK11A-004
ENSP00000351629
ENST00000358779
Q9UQ88 [Direct mapping]
Cyclin-dependent kinase 11A
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0050684 [regulation of mRNA processing]
GO:0051726 [regulation of cell cycle]
Show all
 770 aa
90 kDa 		No 0
CDK11A-005
ENSP00000367900
ENST00000378633
Q9UQ88 [Direct mapping]
Cyclin-dependent kinase 11A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0050684 [regulation of mRNA processing]
GO:0051726 [regulation of cell cycle]
Show all
 783 aa
91.4 kDa 		No 0
CDK11A-007
ENSP00000423900
ENST00000479362
E9PFJ2 [Direct mapping]
Cyclin-dependent kinase 11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 151 aa
18.9 kDa 		No 0
CDK11A-008
ENSP00000348529
ENST00000356200
Q5QPR4 [Direct mapping]
Cyclin-dependent kinase 11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 746 aa
86.8 kDa 		No 0
CDK11A-011
ENSP00000383874
ENST00000401096
Q5QPQ9 [Direct mapping]
Cyclin-dependent kinase 11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 37 aa
4.6 kDa 		No 0
CDK11A-027
ENSP00000367905
ENST00000378638
Q5QPR4 [Direct mapping]
Cyclin-dependent kinase 11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 746 aa
86.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.