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ADAM22
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADAM22

Gene description

ADAM metallopeptidase domain 22

Protein class

Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

ADAM22 (HGNC Symbol)

Synonyms

MDC2

Description

ADAM metallopeptidase domain 22 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

Chromosome

7

Cytoband

q21.12

Chromosome location (bp)

87934143 - 88202889

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000008277 (version 83.38)

Entrez gene

53616

UniProt

Q9P0K1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P0K1

Antibodypedia

ADAM22 antibodies

PROTEIN BROWSER

ADAM22-001
ADAM22-002
ADAM22-003
ADAM22-004
ADAM22-005
ADAM22-006
ADAM22-007
ADAM22-008
ADAM22-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM22-001
ENSP00000265727
ENST00000265727
Q9P0K1 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007417 [central nervous system development]
GO:0008270 [zinc ion binding]
GO:0008344 [adult locomotory behavior]
GO:0014037 [Schwann cell differentiation]
GO:0016021 [integral component of membrane]
GO:0022011 [myelination in peripheral nervous system]
GO:0030424 [axon]
GO:0042063 [gliogenesis]
Show all
906 aa
100.4 kDa
Yes 1
ADAM22-002
ENSP00000381267
ENST00000398209
Q9P0K1 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007417 [central nervous system development]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
Show all
899 aa
100.3 kDa
Yes 1
ADAM22-003
ENSP00000381262
ENST00000398204
Q9P0K1 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007417 [central nervous system development]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
Show all
870 aa
96.6 kDa
Yes 1
ADAM22-004
ENSP00000381260
ENST00000398201
Q9P0K1 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007162 [negative regulation of cell adhesion]
GO:0007417 [central nervous system development]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
Show all
859 aa
95.3 kDa
Yes 1
ADAM22-005
ENSP00000396233
ENST00000426930
H7C0Q9 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
330 aa
36.1 kDa
No 1
ADAM22-006
ENSP00000412085
ENST00000413139
H7C3I4 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
264 aa
29.4 kDa
No 1
ADAM22-007
ENSP00000391334
ENST00000439864
E7EPF1 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
342 aa
39.6 kDa
Yes 0
ADAM22-008
ENSP00000381261
ENST00000398203
F8WAD8 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
804 aa
89.5 kDa
No 1
ADAM22-009
ENSP00000413899
ENST00000412441
E9PF78 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 22
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
196 aa
21.9 kDa
Yes 0

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The Human Protein Atlas project is funded
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