Expression of SPAG9 in cancer - Summary - The Human Protein Atlas

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SPAG9

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPAG9
Gene description	Sperm associated antigen 9
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA040446
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040446

GENE INFORMATION
Gene name	SPAG9 (HGNC Symbol)
Synonyms	CT89, FLJ13450, FLJ14006, FLJ26141, FLJ34602, HLC4, HSS, JLP, KIAA0516, MGC117291, MGC14967, MGC74461, PHET, PIG6, SYD1
Description	Sperm associated antigen 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50962174 - 51120865
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000008294 (version 83.38)
Entrez gene	9043
UniProt	O60271 (UniProt - Evidence at protein level)
neXtProt	NX_O60271
Antibodypedia	SPAG9 antibodies

PROTEIN BROWSER

SPAG9-001	SPAG9-002	SPAG9-003	SPAG9-007	SPAG9-011	SPAG9-012	SPAG9-017	SPAG9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPAG9-001 ENSP00000262013 ENST00000262013	O60271 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001669 [acrosomal vesicle] GO:0005078 [MAP-kinase scaffold activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007257 [activation of JUN kinase activity] GO:0007283 [spermatogenesis] GO:0008432 [JUN kinase binding] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] GO:0030335 [positive regulation of cell migration] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042692 [muscle cell differentiation] GO:0043410 [positive regulation of MAPK cascade] GO:0045666 [positive regulation of neuron differentiation] GO:0048273 [mitogen-activated protein kinase p38 binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051146 [striated muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] GO:0090074 [negative regulation of protein homodimerization activity] Show all	1321 aa 146.2 kDa	No	0
SPAG9-002 ENSP00000349636 ENST00000357122	O60271 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0005078 [MAP-kinase scaffold activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007257 [activation of JUN kinase activity] GO:0007283 [spermatogenesis] GO:0008432 [JUN kinase binding] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] GO:0030335 [positive regulation of cell migration] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042692 [muscle cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0051149 [positive regulation of muscle cell differentiation] GO:0070062 [extracellular exosome] Show all	1307 aa 144.7 kDa	No	0
SPAG9-003 ENSP00000426900 ENST00000505279	O60271 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0005078 [MAP-kinase scaffold activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007257 [activation of JUN kinase activity] GO:0007283 [spermatogenesis] GO:0008432 [JUN kinase binding] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] GO:0030335 [positive regulation of cell migration] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042692 [muscle cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0051149 [positive regulation of muscle cell differentiation] GO:0070062 [extracellular exosome] Show all	1311 aa 145.1 kDa	No	0
SPAG9-007 ENSP00000423165 ENST00000510283	O60271 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0005078 [MAP-kinase scaffold activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007257 [activation of JUN kinase activity] GO:0007283 [spermatogenesis] GO:0008432 [JUN kinase binding] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] GO:0030335 [positive regulation of cell migration] GO:0042147 [retrograde transport, endosome to Golgi] GO:0042692 [muscle cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0051149 [positive regulation of muscle cell differentiation] GO:0070062 [extracellular exosome] Show all	1177 aa 128.6 kDa	No	2
SPAG9-011 ENSP00000426061 ENST00000510855	D6RHI8 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005078 [MAP-kinase scaffold activity] GO:0005622 [intracellular] GO:0007257 [activation of JUN kinase activity] GO:0008432 [JUN kinase binding] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] Show all	156 aa 16.5 kDa	No	0
SPAG9-012 ENSP00000429343 ENST00000511795	H0YBE9 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005078 [MAP-kinase scaffold activity] GO:0005622 [intracellular] GO:0007257 [activation of JUN kinase activity] GO:0008432 [JUN kinase binding] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] Show all	174 aa 19.3 kDa	No	0
SPAG9-017 ENSP00000430205 ENST00000513906	H0YBS5 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005078 [MAP-kinase scaffold activity] GO:0005622 [intracellular] GO:0007257 [activation of JUN kinase activity] GO:0008432 [JUN kinase binding] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] Show all	250 aa 26.3 kDa	No	0
SPAG9-201 ENSP00000484908 ENST00000618113	A0A087X2D8 [Direct mapping] C-Jun-amino-terminal kinase-interacting protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005078 [MAP-kinase scaffold activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007257 [activation of JUN kinase activity] GO:0008432 [JUN kinase binding] GO:0019894 [kinesin binding] GO:0030159 [receptor signaling complex scaffold activity] Show all	1312 aa 145.2 kDa	No	0

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