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Most cancer tissues displayed moderate to strong cytoplasmic and nuclear immunoreactivity. Several cases of lymphomas and few cases of renal and urothelial cancers were weakly stained.
A majority of cancer tissues displayed weak to moderate cytoplasmic immunoreactivity. Several cases of gliomas, lymphomas, squamous cell carcinomas, breast cancers, renal cancers and embryonal carcinomas of testis were negative.
GENE INFORMATION
Gene name
IL32 (HGNC Symbol)
Synonyms
NK4, TAIF, TAIFb, TAIFd
Description
Interleukin 32 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]