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Weak to moderate cytoplasmic positivity was observed in most cancers. Most squamous cell carcinomas, basal cell carcinomas along with several malignant lymphomas and gliomas were negative.
GENE INFORMATION
Gene name
MAPK8IP2 (HGNC Symbol)
Synonyms
IB2, JIP2, PRKM8IPL
Description
Mitogen-activated protein kinase 8 interacting protein 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]