Fields »
ABOUT
HELP
BLOG
PAX7

GENERAL INFORMATION

Gene name

 PAX7

Gene description

 Paired box 7

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, cervical cancer, lung cancer)
HPA (cell line):Group enriched (A549, CAPAN-2, U-2 OS)
HPA (normal tissue):Group enriched (cerebral cortex, skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, cervical cancer, lung cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PAX7 (HGNC Symbol)

Synonyms

 Hup1

Description

 Paired box 7 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 18631006 - 18748866

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000009709 (version 83.38)

Entrez gene

 5081

UniProt

 P23759 (UniProt - Evidence at protein level)

neXtProt

 NX_P23759

Antibodypedia

 PAX7 antibodies

PROTEIN BROWSER
PAX7-001
PAX7-002
PAX7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAX7-001
ENSP00000364524
ENST00000375375
P23759 [Direct mapping]
Paired box protein Pax-7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007519 [skeletal muscle tissue development]
GO:0009653 [anatomical structure morphogenesis]
GO:0010453 [regulation of cell fate commitment]
GO:0010468 [regulation of gene expression]
GO:0014813 [skeletal muscle satellite cell commitment]
GO:0021527 [spinal cord association neuron differentiation]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0031062 [positive regulation of histone methylation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043393 [regulation of protein binding]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048663 [neuron fate commitment]
GO:0048706 [embryonic skeletal system development]
GO:0051216 [cartilage development]
GO:0060415 [muscle tissue morphogenesis]
GO:2000288 [positive regulation of myoblast proliferation]
Show all
 520 aa
56.9 kDa 		No 0
PAX7-002
ENSP00000403389
ENST00000420770
P23759 [Direct mapping]
Paired box protein Pax-7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
Show all
 505 aa
55.1 kDa 		No 0
PAX7-003
ENSP00000383502
ENST00000400661
P23759 [Direct mapping]
Paired box protein Pax-7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
Show all
 518 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.