Cell atlas - MASP2 - The Human Protein Atlas

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MASP2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	MASP2
Gene description	Mannan-binding lectin serine peptidase 2
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029313
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029313	A-431	Golgi apparatus
	HPA029313	Hep G2	Golgi apparatus
	HPA029313	U-2 OS	No staining

GENE INFORMATION
Gene name	MASP2 (HGNC Symbol)
Synonyms	MASP1P1
Description	Mannan-binding lectin serine peptidase 2 (HGNC Symbol)
Entrez gene summary	The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11026523 - 11047233
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000009724 (version 83.38)
Entrez gene	10747
UniProt	O00187 (UniProt - Evidence at protein level)
neXtProt	NX_O00187
Antibodypedia	MASP2 antibodies

PROTEIN BROWSER

MASP2-001	MASP2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MASP2-001 ENSP00000383690 ENST00000400897	O00187 [Direct mapping] Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001855 [complement component C4b binding] GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0008233 [peptidase activity] GO:0045087 [innate immune response] GO:0048306 [calcium-dependent protein binding] GO:0070062 [extracellular exosome] Show all	686 aa 75.7 kDa	Yes	0
MASP2-002 ENSP00000383691 ENST00000400898	O00187 [Direct mapping] Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001855 [complement component C4b binding] GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0008233 [peptidase activity] GO:0045087 [innate immune response] GO:0048306 [calcium-dependent protein binding] GO:0070062 [extracellular exosome] Show all	185 aa 20.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.