Thyroid cancers exhibited strong cytoplasmic positivity. Few cases of colorectal cancers showed weak to moderate staining. Remaining cancers were negative.
IYD (HGNC Symbol)
C6orf71, DEHAL1, dJ422F24.1
Iodotyrosine deiodinase (HGNC Symbol)
Entrez gene summary
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]