Expression of IYD in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

IYD

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IYD
Gene description	Iodotyrosine deiodinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (CACO-2, SK-BR-3)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA059627
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059627

GENE INFORMATION
Gene name	IYD (HGNC Symbol)
Synonyms	C6orf71, DEHAL1, dJ422F24.1
Description	Iodotyrosine deiodinase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Chromosome	6
Cytoband	q25.1
Chromosome location (bp)	150368892 - 150405969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000009765 (version 83.38)
Entrez gene	389434
UniProt	Q6PHW0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PHW0
Antibodypedia	IYD antibodies

PROTEIN BROWSER

IYD-001	IYD-002	IYD-004	IYD-005	IYD-006	IYD-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IYD-001 ENSP00000343763 ENST00000344419	Q6PHW0 [Direct mapping] Iodotyrosine deiodinase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	289 aa 33.4 kDa	No	2
IYD-002 ENSP00000229447 ENST00000229447	Q6PHW0 [Direct mapping] Iodotyrosine deiodinase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	293 aa 33.8 kDa	No	2
IYD-004 ENSP00000376085 ENST00000392256	Q6PHW0 [Direct mapping] Iodotyrosine deiodinase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	247 aa 28.9 kDa	No	2
IYD-005 ENSP00000441276 ENST00000500320	F6VN83 [Direct mapping] Iodotyrosine dehalogenase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	284 aa 32.6 kDa	No	2
IYD-006 ENSP00000376084 ENST00000392255	C9JXJ9 [Direct mapping] Iodotyrosine dehalogenase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	270 aa 31.3 kDa	No	2
IYD-008 ENSP00000390081 ENST00000425615	F5H543 [Direct mapping] Iodotyrosine dehalogenase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	192 aa 22.4 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.