Expression of FAM76A in cancer - Summary - The Human Protein Atlas

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FAM76A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM76A
Gene description	Family with sequence similarity 76, member A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues and additional expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044762

GENE INFORMATION
Gene name	FAM76A (HGNC Symbol)
Synonyms	MGC34648
Description	Family with sequence similarity 76, member A (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p35.3
Chromosome location (bp)	27725979 - 27763122
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000009780 (version 83.38)
Entrez gene	199870
UniProt	Q8TAV0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TAV0
Antibodypedia	FAM76A antibodies

PROTEIN BROWSER

FAM76A-001	FAM76A-002	FAM76A-003	FAM76A-004	FAM76A-005	FAM76A-006	FAM76A-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM76A-001 ENSP00000363065 ENST00000373954	Q8TAV0 [Direct mapping] Protein FAM76A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	307 aa 35 kDa	No	0
FAM76A-002 ENSP00000363060 ENST00000373949	Q8TAV0 [Direct mapping] Protein FAM76A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	278 aa 31.9 kDa	No	0
FAM76A-003 ENSP00000010299 ENST00000010299	Q8TAV0 [Direct mapping] Protein FAM76A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	341 aa 38.5 kDa	No	0
FAM76A-004 ENSP00000234549 ENST00000234549	Q8TAV0 [Direct mapping] Protein FAM76A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	312 aa 35.3 kDa	No	0
FAM76A-005 ENSP00000393171 ENST00000446647	B1AJQ5 [Direct mapping] Protein FAM76A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	124 aa 14.2 kDa	No	0
FAM76A-006 ENSP00000395150 ENST00000419687	Q8TAV0 [Direct mapping] Protein FAM76A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	227 aa 26 kDa	No	0
FAM76A-007 ENSP00000436176 ENST00000530324	E9PQL1 [Direct mapping] Protein FAM76A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000338 [protein deneddylation] GO:0005737 [cytoplasm] GO:0019784 [NEDD8-specific protease activity] Show all	288 aa 33.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.