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MLXIPL

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GENERAL INFORMATION

Gene name

 MLXIPL

Gene description

 MLX interacting protein-like

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus.

RNA cell category

 Cell line enhanced (Hep G2, SCLC-21H, K-562)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA064640
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, SCLC-21H, K-562)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA064640 Hep G2 Nucleus
Cytosol
HPA064640 MCF7 Nucleoplasm
HPA064640 U-2 OS Nucleus

GENE INFORMATION

Gene name

 MLXIPL (HGNC Symbol)

Synonyms

 bHLHd14, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH

Description

 MLX interacting protein-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73593194 - 73624543

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000009950 (version 83.38)

Entrez gene

 51085

UniProt

 Q9NP71 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP71

Antibodypedia

 MLXIPL antibodies

PROTEIN BROWSER
MLXIPL-001
MLXIPL-002
MLXIPL-003
MLXIPL-006
MLXIPL-007
MLXIPL-010
MLXIPL-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MLXIPL-001
ENSP00000320886
ENST00000313375
Q9NP71 [Direct mapping]
Carbohydrate-responsive element-binding protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010255 [glucose mediated signaling pathway]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035538 [carbohydrate response element binding]
GO:0035556 [intracellular signal transduction]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055089 [fatty acid homeostasis]
GO:0070328 [triglyceride homeostasis]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071322 [cellular response to carbohydrate stimulus]
GO:0090324 [negative regulation of oxidative phosphorylation]
GO:2000505 [regulation of energy homeostasis]
Show all
 852 aa
93.1 kDa 		Yes 0
MLXIPL-002
ENSP00000346629
ENST00000354613
Q9NP71 [Direct mapping]
Carbohydrate-responsive element-binding protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010255 [glucose mediated signaling pathway]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035538 [carbohydrate response element binding]
GO:0035556 [intracellular signal transduction]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055089 [fatty acid homeostasis]
GO:0070328 [triglyceride homeostasis]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071322 [cellular response to carbohydrate stimulus]
GO:0090324 [negative regulation of oxidative phosphorylation]
GO:2000505 [regulation of energy homeostasis]
Show all
 831 aa
90.7 kDa 		Yes 0
MLXIPL-003
ENSP00000392636
ENST00000434326
A0A0C4DG26 [Direct mapping]
Carbohydrate-responsive element-binding protein; HCG18989, isoform CRA_h
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0071322 [cellular response to carbohydrate stimulus]
Show all
 721 aa
78.2 kDa 		Yes 0
MLXIPL-006
ENSP00000395172
ENST00000453275
C9JDF5 [Direct mapping]
Carbohydrate-responsive element-binding protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0071322 [cellular response to carbohydrate stimulus]
Show all
 213 aa
23.1 kDa 		Yes 0
MLXIPL-007
ENSP00000402615
ENST00000456640
H7C1V3 [Direct mapping]
Carbohydrate-responsive element-binding protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0071322 [cellular response to carbohydrate stimulus]
Show all
 235 aa
26.7 kDa 		No 0
MLXIPL-010
ENSP00000412330
ENST00000414749
Q9NP71 [Direct mapping]
Carbohydrate-responsive element-binding protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010255 [glucose mediated signaling pathway]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035538 [carbohydrate response element binding]
GO:0035556 [intracellular signal transduction]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055089 [fatty acid homeostasis]
GO:0070328 [triglyceride homeostasis]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071322 [cellular response to carbohydrate stimulus]
GO:0090324 [negative regulation of oxidative phosphorylation]
GO:2000505 [regulation of energy homeostasis]
Show all
 850 aa
92.8 kDa 		Yes 0
MLXIPL-011
ENSP00000406296
ENST00000429400
Q9NP71 [Direct mapping]
Carbohydrate-responsive element-binding protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006112 [energy reserve metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010255 [glucose mediated signaling pathway]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035538 [carbohydrate response element binding]
GO:0035556 [intracellular signal transduction]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055089 [fatty acid homeostasis]
GO:0070328 [triglyceride homeostasis]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071322 [cellular response to carbohydrate stimulus]
GO:0090324 [negative regulation of oxidative phosphorylation]
GO:2000505 [regulation of energy homeostasis]
Show all
 833 aa
90.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.