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ETV7

GENERAL INFORMATION

Gene name

 ETV7

Gene description

 Ets variant 7

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, BJ hTERT+ SV40 Large T+ RasG12V, HDLM-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA029033
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), cervical cancer (favourable) and ovarian cancer (favourable).
Urothelial cancer p<0.001
Cervical cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029033

GENE INFORMATION

Gene name

 ETV7 (HGNC Symbol)

Synonyms

 TEL-2, TEL2

Description

 Ets variant 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 36354091 - 36387800

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000010030 (version 83.38)

Entrez gene

 51513

UniProt

 Q9Y603 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y603

Antibodypedia

 ETV7 antibodies

PROTEIN BROWSER
ETV7-001
ETV7-002
ETV7-003
ETV7-004
ETV7-201
ETV7-202
ETV7-203
ETV7-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ETV7-001
ENSP00000341843
ENST00000340181
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 341 aa
39 kDa 		No 0
ETV7-002
ENSP00000362842
ENST00000373737
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 264 aa
30.8 kDa 		No 0
ETV7-003
ENSP00000342260
ENST00000339796
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 317 aa
36.2 kDa 		No 0
ETV7-004
ENSP00000486712
ENST00000627426
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 262 aa
29.8 kDa 		No 0
ETV7-201
ENSP00000362843
ENST00000373738
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 286 aa
32.6 kDa 		No 0
ETV7-202
ENSP00000440592
ENST00000538992
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 190 aa
22.2 kDa 		No 0
ETV7-203
ENSP00000481885
ENST00000615781
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 282 aa
32.4 kDa 		No 0
ETV7-204
ENSP00000484485
ENST00000620358
Q9Y603 [Direct mapping]
Transcription factor ETV7
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009887 [organ morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 260 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.