Expression of IFFO1 in cancer - Summary - The Human Protein Atlas

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IFFO1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IFFO1
Gene description	Intermediate filament family orphan 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA069344
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA069344

GENE INFORMATION
Gene name	IFFO1 (HGNC Symbol)
Synonyms	HOM-TES-103, IFFO
Description	Intermediate filament family orphan 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6538375 - 6556083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010295 (version 83.38)
Entrez gene	25900
UniProt	Q0D2I5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q0D2I5
Antibodypedia	IFFO1 antibodies

PROTEIN BROWSER

IFFO1-001	IFFO1-003	IFFO1-008	IFFO1-011	IFFO1-201	IFFO1-202	IFFO1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFFO1-001 ENSP00000337593 ENST00000336604	Q0D2I5 [Direct mapping] Intermediate filament family orphan 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005882 [intermediate filament] Show all	562 aa 62.3 kDa	No	0
IFFO1-003 ENSP00000436261 ENST00000465801	E9PPX7 [Direct mapping] Intermediate filament family orphan 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		255 aa 29.3 kDa	No	0
IFFO1-008 ENSP00000380052 ENST00000396840	Q0D2I5 [Direct mapping] Intermediate filament family orphan 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005882 [intermediate filament] Show all	559 aa 62 kDa	No	0
IFFO1-011 ENSP00000349364 ENST00000356896	Q0D2I5 [Direct mapping] Intermediate filament family orphan 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005882 [intermediate filament] Show all	563 aa 62.5 kDa	No	0
IFFO1-201 ENSP00000390721 ENST00000436152	F8W8H2 [Direct mapping] Intermediate filament family orphan 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29.4 kDa	No	0
IFFO1-202 ENSP00000482340 ENST00000615885	F8W8H2 [Direct mapping] Intermediate filament family orphan 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29.4 kDa	No	0
IFFO1-203 ENSP00000482285 ENST00000619571	A0A087WZ16 [Direct mapping] Intermediate filament family orphan 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		571 aa 63.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.