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NISCH

GENERAL INFORMATION

Gene name

 NISCH

Gene description

 Nischarin

Protein class

 FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023189
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023189

GENE INFORMATION

Gene name

 NISCH (HGNC Symbol)

Synonyms

 I-1, IRAS, KIAA0975

Description

 Nischarin (HGNC Symbol)

Entrez gene summary

 This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

Chromosome

 3

Cytoband

 p21.1

Chromosome location (bp)

 52455118 - 52493071

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000010322 (version 83.38)

Entrez gene

 11188

UniProt

 Q9Y2I1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2I1

Antibodypedia

 NISCH antibodies

PROTEIN BROWSER
NISCH-001
NISCH-004
NISCH-014
NISCH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NISCH-001
ENSP00000418232
ENST00000479054
Q9Y2I1 [Direct mapping]
Nischarin
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0055037 [recycling endosome]
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 1504 aa
166.6 kDa 		No 0
NISCH-004
ENSP00000417812
ENST00000488380
C9J715 [Direct mapping]
Nischarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0035091 [phosphatidylinositol binding]
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 583 aa
64.1 kDa 		No 0
NISCH-014
ENSP00000392484
ENST00000420808
Q9Y2I1 [Direct mapping]
Nischarin
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0055037 [recycling endosome]
Show all
 515 aa
56.9 kDa 		No 0
NISCH-201
ENSP00000339958
ENST00000345716
Q9Y2I1 [Direct mapping]
Nischarin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006006 [glucose metabolic process]
GO:0006915 [apoptotic process]
GO:0008217 [regulation of blood pressure]
GO:0016020 [membrane]
GO:0016601 [Rac protein signal transduction]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0048243 [norepinephrine secretion]
GO:0055037 [recycling endosome]
Show all
 1504 aa
166.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.