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Most cancer tissues showed weak to moderate cytoplasmic positivity and additional membrane staining in a few cases. Carcinoids, hepatocellular carcinomas, gliomas, thyroid, prostate, renal and gastric cancers were generally negative.
Cancer tissues displayed weak to moderate cytoplasmic and nuclear positivity. Most cases of gliomas, lymphomas and endometrial cancers were negative.
GENE INFORMATION
Gene name
FUZ (HGNC Symbol)
Synonyms
FLJ22688, Fy
Description
Fuzzy planar cell polarity protein (HGNC Symbol)
Entrez gene summary
This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]