Expression of IDS in cancer - Summary - The Human Protein Atlas

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IDS

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	IDS
Gene description	Iduronate 2-sulfatase
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	IDS (HGNC Symbol)
Synonyms	SIDS
Description	Iduronate 2-sulfatase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the sulfatase family, is localized to the lysosome, and is involved in lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease, mucopolysaccharidosis type II, also known as Hunter syndrome. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	149476990 - 149521096
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010404 (version 83.38)
Entrez gene	3423
UniProt	P22304 (UniProt - Evidence at protein level)
neXtProt	NX_P22304
Antibodypedia	IDS antibodies

PROTEIN BROWSER

IDS-001	IDS-002	IDS-004	IDS-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IDS-001 ENSP00000339801 ENST00000340855	P22304 [Direct mapping] Iduronate 2-sulfatase Iduronate 2-sulfatase 42 kDa chain Iduronate 2-sulfatase 14 kDa chain Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004423 [iduronate-2-sulfatase activity] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	550 aa 61.9 kDa	Yes	0
IDS-002 ENSP00000390241 ENST00000428056	O60597 [Direct mapping] Iduronate 2-sulfatase; Iduronate-2-sulfatase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	179 aa 19.5 kDa	Yes	0
IDS-004 ENSP00000359470 ENST00000370441	P22304 [Direct mapping] Iduronate 2-sulfatase Iduronate 2-sulfatase 42 kDa chain Iduronate 2-sulfatase 14 kDa chain Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004423 [iduronate-2-sulfatase activity] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030207 [chondroitin sulfate catabolic process] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	343 aa 38.3 kDa	Yes	0
IDS-008 ENSP00000429745 ENST00000521702	E5RHJ1 [Direct mapping] Iduronate 2-sulfatase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	86 aa 9.1 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.