Expression of PRSS3 in cancer - Summary

GENERAL INFORMATION
Gene name	PRSS3
Gene description	Protease, serine, 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Cell line enriched (PC-3)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression of exocrine cells in pancreas and in a subset of Paneth cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA062452 , HPA063471
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA062452	HPA063471

GENE INFORMATION
Gene name	PRSS3 (HGNC Symbol)
Synonyms	PRSS4, TRY3, TRY4
Description	Protease, serine, 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	33750466 - 33799231
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010438 (version 83.38)
Entrez gene	5646
UniProt	P35030 (UniProt - Evidence at protein level)
neXtProt	NX_P35030
Antibodypedia	PRSS3 antibodies

PROTEIN BROWSER

PRSS3-002	PRSS3-003	PRSS3-004	PRSS3-201	PRSS3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS3-002 ENSP00000401249 ENST00000457896	B1AN99 [Direct mapping] Trypsin-3 Show all	SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	178 aa 19.4 kDa	No	0
PRSS3-003 ENSP00000354280 ENST00000361005	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	304 aa 32.5 kDa	No	0
PRSS3-004 ENSP00000368715 ENST00000379405	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	247 aa 26.7 kDa	Yes	0
PRSS3-201 ENSP00000340889 ENST00000342836	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	261 aa 28.4 kDa	No	0
PRSS3-202 ENSP00000401828 ENST00000429677	P35030 [Direct mapping] Trypsin-3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0008236 [serine-type peptidase activity] GO:0009235 [cobalamin metabolic process] GO:0031638 [zymogen activation] GO:0043542 [endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	240 aa 25.9 kDa	No	0