Expression of LRRC23 in cancer - Summary - The Human Protein Atlas

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LRRC23

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC23
Gene description	Leucine rich repeat containing 23
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in cilia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA037766 , HPA057533
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037766	HPA057533

GENE INFORMATION
Gene name	LRRC23 (HGNC Symbol)
Synonyms	B7, LRPB7
Description	Leucine rich repeat containing 23 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6873569 - 6914243
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000010626 (version 83.38)
Entrez gene	10233
UniProt	Q53EV4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q53EV4
Antibodypedia	LRRC23 antibodies

PROTEIN BROWSER

LRRC23-001	LRRC23-002	LRRC23-003	LRRC23-008	LRRC23-010	LRRC23-011	LRRC23-013	LRRC23-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC23-001 ENSP00000007969 ENST00000007969	Q53EV4 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	343 aa 39.8 kDa	No	0
LRRC23-002 ENSP00000390932 ENST00000443597	Q53EV4 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	343 aa 39.8 kDa	No	0
LRRC23-003 ENSP00000317464 ENST00000323702	Q53EV4 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	312 aa 36.1 kDa	No	0
LRRC23-008 ENSP00000396049 ENST00000436789	C9JEW3 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	216 aa 24.8 kDa	No	0
LRRC23-010 ENSP00000397192 ENST00000429740	E9PDZ4 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	202 aa 23.4 kDa	No	0
LRRC23-011 ENSP00000402554 ENST00000433346	C9JKE8 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	230 aa 26.5 kDa	No	0
LRRC23-013 ENSP00000408066 ENST00000415834	C9JQN5 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Show all		94 aa 11 kDa	No	0
LRRC23-201 ENSP00000479128 ENST00000622489	E9PDZ4 [Direct mapping] Leucine-rich repeat-containing protein 23 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	202 aa 23.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.